Authorities identified the suspect as 27-year-old Camden Burton Nicholson, of Newport Beach. He was booked at Orange County Jail on suspicion of homicide.
The identities of the victims were not immediately released. The causes of death were not disclosed.
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The investigation began shortly before 9 p.m. Wednesday when Newport Beach police received a call from Irvine police requesting a welfare check at a home in the 30 block of Palazzo. Irvine authorities were in contact with a man at UC Irvine Medical Center's ER.
Officers responded to the residence, where they discovered the deceased individuals: two women and one man. A homicide investigation was launched.
"It appears that all the involved parties were known to each other and there is no ongoing threat to the area," the Newport Police Department said in a statement.
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The man at the ER was detained and later booked for murder.
Anyone with information about the case is asked to call police Detective Prince at (949) 644-3762.