It happened in North Hills near the intersection of Nordhoff Street and Burnet Avenue Thursday night.
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Witnesses say one of the drivers ran away from the crash scene and left behind another driver injured.
Paramedics took that injured person to a nearby trauma center in an unknown condition.
The crash also resulted in a fire hydrant being sheared off and sending a huge geyser of water into the air.
One of the vehicles jumped a curb, skidded down the sidewalk and slammed into a fence at a very large apartment complex, according to investigators.
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Many people in the neighborhood came out to take a look at all the damage.
The search for the driver who ran away is ongoing.