The incident was reported about 2:44 a.m. near Colfax Avenue, where the big rig and a white Hyundai sedan collided, according to a California Highway Patrol incident log. No injuries were reported.
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The semi began leaking diesel fuel on the roadway after the impact, prompting the CHP to issue a Sigalert. Caltrans crews responded to the scene and used brooms and an absorbent to clean up the spill.
One westbound lane was intermittently opened during the cleanup. Eastbound traffic was unaffected.
All lanes were reopened as of 8:30 a.m., the Highway Patrol said.
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A CHP spokesperson confirmed an arrest was made in the incident, but no other details were immediately available.
The cause of the collision is under investigation.