It happened around 6:41 p.m. near Lassen Street and Amestoy Avenue. Investigators said a total of three vehicles were involved. The driver of one of those vehicles reportedly crossed over into oncoming traffic and was later arrested on suspicion of DUI. That driver's identity has not yet been released.
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The Los Angeles Police Department said a total of six people were rushed to the hospital, one of whom had had to be extricated from a vehicle. Another person suffered severe injuries while the rest sustained non-life-threatening injuries.
It's unclear what led up to the collision.
Video from the scene shows two vehicles with serious damage.
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The crash remains under investigation.