The driver of the vehicle, whose name was not released, was later arrested on suspicion of driving under the influence, Santa Ana police said Sunday afternoon.
According to the Santa Ana Police Department, the collision was reported shortly before 5:30 a.m. near the intersection of 17th and French streets.
The white Nissan Altima crossed three lanes on 17th before it hit a center divider, soared into the air and plowed into the two-story structure, the Orange County Fire Authority said.
The incident caused a small fire that injured one person, who managed to get out of the sedan unassisted, the OCFA said.
Firefighters responded to the scene and extinguished the blaze, then extricated a second person who was trapped inside the sedan.
Police say the center median had a dirt mound which likely contributed to the car launching into the air. They say no other vehicles were involved in the incident.