An officer was shot in the leg during the confrontation with the suspects, but was treated and released from a hospital.
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The incident happened just before 7:30 p.m. in the area of Melrose and Fairfax avenues.
Police say there was an armed robbery at a business in the area. The suspects were trying to steal a high-end watch from a customer at the store.
The suspects shot at the officers whey they arrived at the scene, police said.
LAPD says they are still searching for the suspects, who got away in an SUV. They were wearing ski masks at the time of the attempted robbery.
The customer involved in the attempted robbery was not seriously injured, and his watch wasn't stolen.
LAPD initially said a suspect was wounded by gunfire, but later said no one else was injured except for the officer.
Streets were being closed in the area during the investigation.
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A description of the suspects was not immediately available.