No officers or witnesses were injured, but the suspect was struck and sustained injuries that were not believed to be life-threatening, the LAPD says.
The incident happened around 12:30 p.m. in the area of West Pico Boulevard and Kenmore.
LAPD officials say two officers were driving down Pico in a department vehicle when someone opened fire at them. Bullets struck the windshield of the SUV but the officers were not injured.
"Officers did return fire and a foot chase ensued," said LAPD Sgt. Bruce Borihanh. "They chased the suspect a couple of blocks down to Pico and Berendo, where a use of force occurred and they did take the suspect into custody."
The suspect was wounded by the officers' gunfire and was transported to a nearby hospital. A handgun was recovered. The suspect was described as a man in his 30s. His condition was considered stable.
Traffic in the area was expected to be impacted for hours while officials investigate the incident.