The accident at the intersection of Westminster Avenue and North Euclid Street was reported at 12:11 a.m., according to the OCFA.
Two of the injured were sent to a trauma center and eight were hospitalized, fire officials said.
The fireworks were professional grade and Santa Ana police were not investigating the accident, according to the department. However, the accident was being investigated by the OCFA.
City News Service contributed to this report.