The first 10 inductees will include Kobe Bryant, Walt Disney, Gwen Stefani and Tiger Woods.
The inaugural Hall-of-Fame ceremony will be held Friday starting at 10 a.m. in Santa Ana at the county administration building.
The public will be able to watch the ceremony live on YouTube at this link.
Inductees represent achievements in music, arts and entertainment, sports, business, philanthropy and civics.
The Orange County Board of Supervisors last year voted to establish the Hall of Fame "to recognize and honor the individuals who have significantly contributed to the fabric of Orange County's rich cultural, societal, and professional landscape," according to a county statement.