Instead, the county will focus more on mobile vaccination clinics to provide shots in areas where there is more resistance to getting the jab in the arm.
The Super Point-of-Dispensing, or POD, sites at the Anaheim Convention Center, OC Fair & Event Center, Soka University and Santa Ana College will shut down on June 5.
Officials say first-dose appointments have dropped 75 percent since the end of April.
According to state data, more than 2-point-6 million vaccine doses have been administered in the county.
More than 1 million O.C. residents are now fully vaccinated.
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The county meets two of the three categories for the least-restrictive yellow tier of the state's four-tier system for reopening the economy, but remained in the orange tier after the weekly rankings were released Tuesday.
Orange County's weekly average of daily new cases per 100,000 residents improved from 2.6 to 2.4. A graduation into the yellow tier requires that the case rate must get below 2 per 100,000 people. A county must maintain metrics for a tier for two weeks before graduating to a less-restrictive level.
The overall test positivity rate improved from 1.4% to 1.3%. And the county's Health Equity Quartile rate, which measures positivity in hotspots in disadvantaged communities, declined from 1.9% to 1.4%.
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City News Service contributed to this report.