Police received a call at around 12:30 a.m. about a shooting on East Culver Avenue near South Cambridge Street.
When officers arrived on scene, they found an adult male who had been shot. He was transported to an area hospital, where he was pronounced dead.
No arrests have been made, and police did not have a description of the suspect or suspects involved.
It was unclear if the shooting was gang related.
If you have any information about this ongoing investigation, you're urged to contact the Orange Police Department at (714) 744-7444.