Los Angeles police and paramedics were called to the school around 2 p.m. on reports the teen was suffering from symptoms indicating a drug overdose.
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It was not immediately known what substance the student ingested, but LAPD says school staff administered the anti-overdose drug Narcan. The student is in stable condition.
Friday's incident marks the second time a student at Bernstein High School suffered a drug overdose in just over a month.
In September, a teenager was arrested for allegedly selling a fentanyl-laced drug that killed student Melanie Ramos. She was 15 years old.
Following her death, the Los Angeles Unified School District said it would provide all schools with Narcan to prevent future tragedies.
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City News Service contributed to this report.