AIR7 HD was over the scene around 8:45 a.m. near the intersection of Pacific Coast Highway and Chautauqua Boulevard where it appeared an SUV, two sedans and a box truck had collided.
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Caltrans initially tweeted that the crash "involved a fatality." A Los Angeles Police Department later said no one was killed in the incident.
Both directions were blocked off, with northbound traffic being diverted to the shoulder.
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All lanes were reopened in both directions by 12:48 p.m., according to Caltrans.
It is unclear what led to the crash.