Authorities said the crash happened around 6:15 p.m. near the San Fernando Road exit as two senior citizens were stuck inside the car.
Firefighters were able to safely extract the couple and place them in an ambulance. They were listed in fair condition.
The man and woman were alert and talking with crews as they were rescued.
It was unclear how the vehicle flipped over and crashed.
Traffic was backed up for a few miles as they were diverted off the freeway. It reopened about an hour later.
The investigation is ongoing.