The crash happened Sunday just before 9 p.m. in the 13000 block of Roscoe Boulevard, just east of the Tujunga Wash, and was partially captured by a surveillance video camera mounted on a nearby home.
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The footage shows a shower of sparks emanating from a moving vehicle after it lost a tire.
According to authorities, one of the vehicles rolled over and the driver was killed when he was ejected. Another car was wrecked nearby.
The fire department said four people suffered minor injuries. A power pole was toppled in the collision.
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The cause of the crash remains under investigation.
According to the Los Angeles Police Department, one witness said a driver was driving recklessly and at a high rate of speed before the impact.
"When the wheel fell off ... he hit a post," the witness said in a news interview at the scene, "and then the guy went out, flying."