AIR7 HD was above the scene at W Pico and La Cienega boulevards where a black car was spotted crashed on the sidewalk in front of a Chase bank.
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Several Los Angeles Fire Department crews were seen treating some of the patients.
Investigators told ABC7 at least three people were sent to the hospital, including a 48-year-old woman and a 51-year-old man who were in critical condition. The man later died at the hospital, police said.
The third person injured is a 19-year-old.
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It's unclear what caused the collision. The driver reportedly did not want to be transported to the hospital.
The driver remained at the scene and cooperated with police. No arrest was made.