Few details were immediately available about the collision, which was reported shortly after 9 p.m. at the intersection of 98th Street and Western Avenue, according to the Los Angeles Police Department.
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One victim was pronounced dead at the scene but was not immediately identified. The other pedestrian was transported to a hospital in unknown condition.
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Whether the driver remained at the scene was unclear.
News video showed a red Ford Mustang with front-end damage and a shattered windshield being towed from the crash site.