Few details were immediately available about the collision, which was reported shortly after 9 p.m. at the intersection of 98th Street and Western Avenue, according to the Los Angeles Police Department.
One victim was pronounced dead at the scene but was not immediately identified. The other pedestrian was transported to a hospital in unknown condition.
Whether the driver remained at the scene was unclear.
News video showed a red Ford Mustang with front-end damage and a shattered windshield being towed from the crash site.