It happened just after 10 p.m. near Pico Boulevard and Vermont Avenue.
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Police told Eyewitness News the driver of what was described as a white compact car hit the pedestrian and took off.
The driver was last seen heading southbound on Vermont Avenue.
A Metro bus may have also possibly hit the pedestrian after the initial crash, according to police.
The bus driver reportedly contacted LAPD and stayed at the scene.
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The area is currently blocked off as officers continue their investigation.