The incident involving the single-engine aircraft occurred about 12 p.m. in the 2500 block of Navy Way, according to the Los Angeles Fire Department.
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Bystanders pulled the male pilot from the wreckage and were directed in providing CPR by a Fire Department dispatcher until firefighters arrived and assumed medical care, the agency said in a statement. That man was pronounced dead at the scene.
The hospitalized occupant of the truck was identified only as a 30-year-old man.
News video from the scene showed the wreckage of the fixed-wing aircraft near the damaged semi-truck, which did not have a trailer attached.
Authorities described the location as an isolated area of the port, adding that port operations were not affected.
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The Federal Aviation Administration and the National Transportation Safety Board were on scene to conduct an investigation into the cause of the crash.
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