The chase started in the afternoon on the 605 Freeway in the Santa Fe Springs area.
The CHP says the driver of the silver convertible failed to yield and led officers on a high-speed chase.
The suspect hopped on the 10 Freeway going east at speeds over 120 mph.
The car crashed into a Los Angeles County Sheriff's Department inmate bus in Pomona - but no inmates were on board. It ended up on its side, wedged between the bus and the center divider of the freeway.
The driver jumped out and was arrested immediately.