The crash, involving a 2002 Honda Accord, was reported just after 6 p.m. near the Sherman Way exit of the 405.
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One victim was pronounced dead at the scene after suffering massive crush injuries, according to the Los Angeles Fire Department.
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Three patients were transported to a hospital -- two in serious-to-critical condition. The other person was in fair condition, with injuries that were described as non-life threatening.
Haskell Avenue was closed near the crash site as an investigation got underway.