Authorities responded to the area of Vermont Avenue and 88th Street just after 12:30 p.m. Wednesday.
The victims pulled their car up alongside the Monarch Liquor store, one man got out, and that's when sheriff's deputies say another car rolled up beside them.
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"One of the occupants of the vehicle stepped out of the vehicle and fired at the victims," sheriff's Lt. Holly Francisco said.
A 26-year-old man, identified by witnesses as Michael, was declared dead at the scene.
The two other men in the vehicle were rushed to area hospitals in unknown condition. A fourth victim, a woman, was shot a couple of blocks away near 90th Place and Vermont Avenue. She was transported to a local hospital in unknown condition.
The suspect was described as an African-American male in a four-door light-colored car.
Investigators were hoping to interview the victims in the hospital, but at this point they suspect the shooting is gang-related.
No further information was immediately available. Anyone with information about this incident is encouraged to contact the Los Angeles County Sheriff's Department's Homicide Bureau at (323) 890-5500.