The incident happened around 7:30 p.m. Wednesday at the intersection of 66th and Holmes streets, according to the Los Angeles County Sheriff's Department.
When deputies arrived, they found a man in one of the cars dead from apparent gunshot wounds. The victim has not been identified.
A view from AIR7 over the scene showed a sedan and SUV with significant damage.
Further details about the crash and who may have shot the victim were not available. No arrests have been made.