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The crash happened Monday night after a car stalled in the slow lane just south of Hodge Road.
A good Samaritan stopped nearby and used a spotlight to warn other drivers. However, a semi-truck didn't stop in time and slammed into the stalled sedan.
The California Highway Patrol and fire crews rushed in and tried CPR, but the driver in the sedan did not survive.
The semi-truck driver stayed on scene to cooperate with investigators.