It happened just before 2 a.m. near W 53rd Street and Broadway in the South Park area.
One person was pronounced dead at the scene and one person was taken to a hospital in serious condition, authorities said.
Two are in fair condition.
Video from the scene showed a mangled vehicle on its side in the middle of the street.
It's unclear what caused the collision but police say one person was detained and is being investigated for possible DUI.