The deadly incident happened on eastbound lanes near Euclid Street just before 9:30 p.m. Wednesday, according to the California Highway Patrol.
The CHP said the suspect vehicle is a semi-truck, but the driver apparently drove away from the scene.
Video from the scene showed a silver sedan flipped onto its roof. That car had three people inside, who had to be pulled out by first responders.
One person died at the scene and two others were hurt, but the extent of the injuries were unknown.