The crash was reported at 5:44 a.m. in the 1000 block of Venice Boulevard, two blocks north of the 10 Freeway, an LAPD spokesperson said.
One person was transported to a medical center in unknown condition, and four others who complained of pain were treated at the scene, the police spokesperson said.
Whether a pedestrian was among the victims was not immediately confirmed.
"The safety of our riders and other road users is our top priority," a Waymo spokesperson said in a statement provided to ABC7. "We are coordinating with first responders and are grateful for their quick response."
The cause of the crash is under investigation.