The two-car collision happened on SR-126 near Fine Road just after 2:20 p.m., according to a California Highway Patrol traffic log.
Multiple other people were injured in the crash, according to the traffic log.
"Traffic is backed up over a mile in both directions," the CHP posted on X just before 4 p.m. "We are alternating traffic to keep it moving. Please avoid the area."
Footage from the scene showed traffic at a standstill and two mangled cars on the side of the road. It's unclear what caused the crash.