The crash, which involved five cars, was reported at La Brea and Beach avenues around 8:45 a.m., according to the Los Angeles County Fire Department.
Details about what led up to the crash were not available, but some of the victims were reportedly trapped inside some of the cars.
Two people, who have not been identified, died at the scene. Two others were taken to the hospital, one of them with critical injuries.
DEVELOPING: We will add more details to this report as they become available.