The crash was reported around 3:15 a.m. at the Lincoln Avenue off-ramp, according to the California Highway Patrol's traffic log.
Details surrounding the circumstances leading up to the crash were limited, but only one car appeared to be involved. Two people were reportedly thrown out of the car.
A view from AIR7 showed officers investigating the wreckage of the crash located in a grassy embankment area along the freeway.
The two injured people were taken to the hospital in unknown condition, according to the Metro Cities Fire Authority.
The two right lanes and the off-ramp were blocked to morning traffic as authorities investigated the deadly crash.
DEVELOPING: We will add more details to this report as they become available.