Missiles fired by Navy ships and massive military maneuvers are said to be planned as part of the Marine Corps' 250th anniversary celebration.
UPDATE: The Marines have since said the 5 Freeway will not be shut down this weekend. Read our latest report here.
Vice President JD Vance and Defense Secretary Pete Hegseth are both scheduled to attend the event titled "Sea to Shore - A Review of Amphibious Strength".
The event could include Navy ships firing live military ordnance over the 5 Freeway and onto Camp Pendleton.
As a result, the 5 Freeway could be closed from Friday to Saturday between Los Angeles and San Diego for an unknown amount of time, the Los Angeles Times reported.
The closure would impact about 80,000 travelers a day and likely cause a gridlock from Dana Point in the north to past Del Mar in the south.
Governor Gavin Newsom responded to the plans on X, saying "Donald Trump and JD Vance think that shutting down the I-5 to shoot out missiles from ships is how you respect the military."
"Put aside your vanity parade and pay our troops instead," Newsom added.
Amid the ongoing government shutdown, the president directed the Pentagon to reallocate unused funds to pay the military.
"1.3 million active duty service members would be missing a paycheck, they will get their check thankfully because President Trump has shown strong leadership," said House Speaker Mike Johnson.
But hundreds of thousands of federal employees, like air traffic controllers, are still working without pay.
"Not knowing how I'm going to have child care for my kids, put gas in the car or pay the next mortgage payment, adds a certain level of stress to an already stressful profession," said air traffic controller Peter Lefevre.
House Minority Leader Hakeem Jeffries said, "We are ready, willing to negotiate a bi-partisan spending agreement, that actually meets the needs of the American people."
Another vote to fund the government failed Wednesday for a ninth time as the shutdown heads into the third week.
The celebration also coincides with another round of "No Kings Day" protests planned for this weekend.
The demonstrations are expected to bring out millions across the country who oppose the administration.