Beutner's decision comes after the death of his 22-year-old daughter last month. Her cause of death has not been released.
"My family has experienced the unimaginable loss of our beloved daughter Emily. She was a magical person, the light of our lives. We are still in mourning," he said in a statement. "A successful campaign, and more importantly the job of Mayor, requires someone who is committed 24/7 to the job. Family has always come first for me. That is where I need to be at this time."
Beutner served as LAUSD Superintendent from 2018 to 2021.