The fire was reported around 7 p.m. Sunday on National Trails Highway near Victorville, according to Battalion Chief Steve Tracy. More than 200 firefighters were on scene the following morning.
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At one point, the fire had burned 80 acres.
The San Bernardino County Fire Department said three vacant homes - two of which are mobile homes - were damaged in the fire. The house had apparently suffered damage from a previous fire, officials said.
Structures located between the Mojave River bottom and National Trails Highway have been evacuated though many of the homes are empty, authorities said.
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Tracy told Eyewitness News it would take several days for crews to completely extinguish the fire.
No injuries were reported.