The break-in unfolded around 1:30 a.m. Wednesday on Dilling Street between Beck and Colfax avenues, according to the Los Angeles Police Department.
A security guard said he saw two suspects entering the property and breaking a glass black door to get into the home.
"Broke in, entered, went upstairs, robbed a whole bunch of jewelry and clothes and before I could come back through the back, they were already out. Had to call 911... I wasn't harmed today but I don't know if they were armed and I was trying to play it safe," he said.
The residents were not home at the time.
Additional details were not available.