The chase, which lasted more than an hour, ended with a standoff on the 5 Freeway near Lake Hughes Road in the Castaic area. Several California Highway Patrol officers approached the suspect and arrested her without incident.
At one point during the standoff, the suspect exited the minivan holding a dog that was in the passenger seat during the pursuit.
Los Angeles police say the suspect may be connected to a shooting in Echo Park that wounded two people.
WATCH: Shooting suspect makes U-turn, dodges several police cars
Chase: Shooting suspect makes U-turn, dodges police cars
AIR7 was over the pursuit just before 4:40 p.m. Thursday as the female driver fled in a minivan on the northbound 170 Freeway in North Hollywood.
The pursuit almost ended in Sun Valley when police cornered the suspect, but she made a U-turn and maneuvered past several police cars.
From there, the suspect got on the 5 Freeway and entered the Santa Clarita Valley.
The chase eventually came to an end after the suspect drove over a spike strip that flattened at least one tire.
Los Animal Services will investigate who owns the dog and could release the animal back to the suspect if she's determined to be the owner.