Two vehicles crashed at the intersection of Colorado Boulevard and Fair Oaks Avenue around 6 a.m., sending one sedan careening backwards into the front glass of the building.
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Firefighters say one person was taken to the hospital with minor injuries.
Crews are evaluating the restaurant and building for structural stability.
That particular Cheesecake Factory - located at a busy intersection in the popular Old Pasadena district - was also the site of a similar crash in 2017, as well as an explosion.
On Feb. 2, 2017, a man threw a homemade device into the restaurant, setting off an explosion that frightened diners but did not cause any serious injuries.
Man sets off explosive at Cheesecake Factory in Pasadena
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Man sets off explosive at Cheesecake Factory in Pasadena; no injuries
On Tuesday, a FBI spokesperson confirmed the suspect is still outstanding in the explosion.
A few days after that incident, two cars crashed at the nearby intersection, sending one of the vehicles careening into the glass.
Car slams into front of Cheesecake Factory in Pasadena