According to the San Bernardino County Sheriff's Department, the crash occurred around 4 p.m. near the intersection of Bear Valley and Kiowa roads. The deputy was heading westbound on Bear Valley Road with emergency lights and sirens on.
The sheriff's department said the driver of a Toyota Corolla was heading eastbound on Bear Valley Road - west of Kiowa Road - when he tried to make a left turn into a parking lot, colliding with the deputy's vehicle.
The driver, who has not yet been identified, died at the scene.
The deputy suffered only minor injuries. No further details were released.
Meanwhile, Bear Valley Road between Kiowa Road and Snapping Turtle will be closed for several hours while deputies conduct their investigation.