Officers responded at 9:50 p.m. to reports of a stabbing in the 8900 block of Orion Avenue and Rayen Street, just east of the 405 Freeway, a spokesperson for the Los Angeles Police Department said.
News video from the scene showed paramedics placing the victims, each of whom was on a stretcher, into an ambulance.
The injured man and woman were both listed in stable condition at a hospital.
A description of the suspect was not immediately available.
Whether the victims knew the assailant was unclear, the LAPD spokesperson said. The motive for the stabbings was under investigaiton.