The crash happened around 12:30 a.m. Wednesday near Reseda Boulevard and Rosita Street, according to the Los Angeles Police Department.
Firefighters worked quickly to extinguish the flames. Video from the scene appears to show multiple cars in the driveway that were also damaged.
It's unclear if anybody was inside the home at the time.
An ambulance was called to the scene, presumably for injuries that the driver sustained. That individual was arrested on suspicion of DUI.