The fire was reported around 1 a.m. Monday on Dillon Street, according to the Los Angeles Fire Department. Firefighters arrived to find smoke pouring from a Target store, which sits on the first level of the building.
The flames were contained to the commercial part of the building, but nearly 50 apartment units that sit above the store were evacuated.
Everyone made it out safely and no injuries were reported.
Details about what started the fire were not immediately available.