Bass said businesses have seen a drastic reduction in immigrant customers. She's concerned some immigrant families whose breadwinners have been rounded up by Immigration and Customs Enforcement may be on the brink of being left destitute.
"When one breadwinner, one wage earner, is gone and disappears - to survive in our city, economically, you need two, three and four wage earners to keep housing, to keep food on the table, to keep clothes on your kids," Bass said.
"When that is taken away from you that just doesn't destabilize a family, that destabilizes a neighborhood," the mayor added. "It destabilizes businesses. It destabilizes a community."
Last week, a federal appeals court ruled to uphold a lower court's temporary order blocking the Trump administration from conducting indiscriminate immigration stops and arrests in Southern California.
U.S. Attorney Bill Essayli says immigration enforcement will continue in the region, adding the enforcement of federal law is not negotiable.
The L.A. region has been a battleground with the Trump administration over its aggressive immigration strategy that spurred protests and the deployment of the National Guards and Marines for several weeks.
Federal agents have rounded up immigrants without legal status to be in the U.S. from Home Depots, car washes, bus stops, and farms, many who have lived in the country for decades.
The Associated Press contributed to this report.