The incident began around 7 a.m. Friday on the north Main Street overpass above the 101 Freeway.
According to the Los Angeles Fire Department, there was "a female patient on the Main St x 101 Fwy overpass experiencing a behavioral emergency".
All lanes reopened around 8 a.m., according to the California Highway Patrol.
LAFD said "The patient is now safely with LAPD and LAFD. Firefighter/paramedics will conduct an assessment".
Air7 was over the scene around 7:40 a.m. as traffic was diverted off the freeway. Traffic was backed up for miles on the 101 as a result of the closure.
No further details were immediately available.