The crash was reported around 7:44 p.m. at the intersection of Burbank and Balboa boulevards.
When firefighters arrived, they had to use hydraulic tools to extricate two patients. Two people were transported in critical condition to a local trauma center and a third person was evaluated at the scene but declined transport.
LAPD says one officer was also brought to a local hospital with minor injuries.
AIR7 HD footage of the aftermath showed the LAPD SUV with heavy front-end damage. A red Toyota Corolla had careened onto the sidewalk and became wedged between a light pole and a concrete wall. It appears that vehicle was the one involving occupants who had to be extricated. A third car, a white Chevy Camaro, was also damaged in the intersection.
The cause of the crash remains under investigation. Police said the LAPD vehicle was not involved in a pursuit at the time of the crash.