Officers responded to a domestic violence call shortly before 9:30 p.m. in the 500 block of West 37th Street, just west of Pacific Avenue, according to the Los Angeles Police Department.
The officers were dispatched to an apartment regarding a report of an individual allegedly violating a restraining order, police said.
When they arrived, they made contact with the suspect and tried to detain him but a physical altercation ensued. That's when shots were fired.
The suspect was struck by gunfire and taken to a hospital where he later died.
Two officers were taken to a hospital after suffering minor injuries during the altercation, the LAPD said.
No other details were immediately available.