According to the Los Angeles Department of Water and Power, a 24-inch pipe burst around 3:30 a.m. on Manchester Avenue at Hoover Street, flooding the area.
Manchester Avenue from Vermont to the 110 Freeway looked like a river as crews worked to repair the break.
Eventually, crews dug a large hole in the ground to turn off the water and replace the pipe. Bulldozers worked for hours to clear the scene and scrape mud off the roadways.
With the water shut off, neighbors say their Thanksgiving plans have been impacted.
"The water is off at my house. So, it's hard to do our last-minute cooking and all that. So, I'm just waiting for them to turn the water back on," said resident Walter Pratt Jr.
"I know, especially my mom, she's cooking a lot for our family right now. I don't think she's going to be able to get a lot of that done," said Ian Scott.
Service to hundreds is being affected, including homes, apartment buildings, commercial buildings and businesses.
Crews on scene said the water may not be turned back on for all residents until Thursday evening. Some stretches of Manchester Avenue will remain closed until approximately 8 p.m., when the repairs are expected to be completed.
The cause of the water main break is still under investigation.