The blaze was reported before 1:30 p.m. at a commercial structure in the 2900 block of East Imperial Highway, according to the Los Angeles County Fire Department.
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No injuries were immediately reported, and it was unclear if the auto shop was open for business when the fire began.
Firefighters battle 3-alarm blaze at auto body shop in Lynwood
News video from the scene showed firefighters dousing massive flames with water and working to protect nearby buildings.
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"Knockdown of the fire is expected soon," the Fire Department tweeted shortly after 2 p.m.
The cause of the fire was unknown.