The altercation occurred shortly before 11:20 p.m. near the intersection of Sixth Street and Maple Avenue, a spokesperson for the Los Angeles Police Department said.
After attacking the victim, the suspect fled the scene and remained at large. A detailed description of him was not available.
The mortally wounded man was transported to a hospital, where he was pronounced dead. His identity was not immediately released.
The circumstances that led to the argument were unclear.