The crash was reported around 10:30 a.m. on North Arleta Avenue near Terra Bella Street, according to the Los Angeles Fire Department.
Los Angeles police said investigators believe the bus ran a red light.
As many as 7 injured after multi-car crash involving school bus, LAFD says
Officials said the patients were being assessed at the scene but all were refusing to be taken to the hospital. The fire department does not believe any students were on the bus.
Four other cars were involved in the crash.