The crash was reported at 9:20 a.m. near the intersection of Third Street and Rowan Avenue, involving an E Line train and a black sedan. The number of people onboard the train and in the car was unclear.
The condition of the person taken to the hospital was not immediately known.
E Line service was disrupted due to the collision near Metro's Indiana station, the agency said, urging riders to follow @metrolaalerts on X for updates.
The cause of the crash is under investigation.